P38 Signaling Pathway
Material type:
TextLanguage: English Publication details: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021Description: 1 online resource (194 p.)Content type: - text
- computer
- online resource
- 9783036508580
- 9783036508597
- books978-3-0365-0859-7
- Research and information: general
- alveolar epithelial type II cells
- Alzheimer's
- Alzheimer's disease
- amyloid-β
- anxiety
- arginine methylation
- arrhythmia
- bleomycin-induced pulmonary fibrosis
- cancer
- cocaine
- conditioned place preference
- depression
- endosome
- energy metabolism
- erythroid differentiation
- exercise
- hippocampus
- hypoxia
- idiopathic pulmonary fibrosis
- inflammation
- k opioid receptors
- Kv4.2
- Lewy Bodies
- MAPK
- MAPK11
- metabolism
- MKK3
- n/a
- neuroinflammation
- neuronal firing and excitability
- nuclear translocation
- nucleus accumbens
- p38
- p38 MAPK
- p38 mitogen-activated protein kinase
- p38-MAPK α inhibitor
- p38MAPK
- p38α
- p38β
- phosphorylation, PRMT1
- physiology
- Rab5
- reward
- RNA sequencing
- seizure
- signal transduction
- signaling
- skeletal muscle
- social interaction
- stress
- synaptic plasticity
- tau
- Tau
- temporal lobe epilepsy
- type 2 diabetes
- α-synuclein
- β-amyloid
- β-like importins
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p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.
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