From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials
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TextLanguage: English Publication details: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021Description: 1 online resource (188 p.)Content type: - text
- computer
- online resource
- 9783036501123
- 9783036501130
- books978-3-0365-0113-0
- Humanities
- Social interaction
- 3D culture
- advanced in vitro model
- AgNP
- Allium cepa
- aluminum
- antioxidant activity
- apoptosis
- BEAS-2B cells
- CeO2NP
- comet assay
- cytotoxic
- cytotoxicity
- DNA damage
- DNA methylation
- epigenetics
- FPG enzyme
- genotoxic
- genotoxicity
- graphene oxide
- gut
- hepatotoxicity
- HepG2
- high throughput screening
- Hprt
- Hs27 human fibroblasts
- human amniotic cells
- in vitro genotoxicity
- in vitro testing
- lincomycin
- liver
- liver spheroids
- metal oxides
- metal/coating agent ratio
- micronuclei formation
- micronucleus
- micronucleus assay
- multi-walled carbon nanotubes (MWCNT)
- n/a
- nanomaterial
- nanoparticles
- nanoplastics
- nanotoxicology
- nongenotoxic silver nanoparticles
- oral route
- oxidative stress
- polystyrene nanoparticles
- reduced graphene oxide
- safer-by-design
- silver ions
- SiO2NP
- TiO2NP
- titanium dioxide nanoparticles
- tritiated particles
- tungsten
- V79 cells
- ZnONP
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This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage-the first step in carcinogenesis-must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.
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