Neuropsychopharmacology of Psychosis: Relation of Brain Signals, Cognition and Chemistry (Record no. 110237)
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| 001 - CONTROL NUMBER | |
| control field | doab54531 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | oapen |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250110172553.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr|mn|---annan |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210211s2015 xx |||||o ||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-2-88919-335-6 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9782889193356 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/978-2-88919-335-6 |
| Source of number or code | doi |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | oapen |
| Transcribing agency | oapen |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 042 ## - AUTHENTICATION CODE | |
| Authentication code | dc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | M |
| Source | bicssc |
| 245 00 - TITLE STATEMENT | |
| Title | Neuropsychopharmacology of Psychosis: Relation of Brain Signals, Cognition and Chemistry |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Name of publisher, distributor, etc. | Frontiers Media SA |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (276 p.) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 490 1# - SERIES STATEMENT | |
| Series statement | Frontiers Research Topics |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| Standardized terminology for access restriction | Unrestricted online access |
| Source of term | star |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Previous research over the past decades has identified diverse neurobiological underpinnings of psychosis. In particular, by combining a variety of different neuroimaging modalities, it has been shown that psychotic states and the actual transition phase from a clinical high-risk state to established psychosis is characterized by structural, functional and neurochemical changes across different brain regions. Further evidence revealed that maybe not only focal brain abnormalities are characteristic for psychosis but specifically also an abnormal functional integration among various brain areas. Some evidence also suggests that dysfunctional brain connectivity proceeds during the development of psychosis when subjects perform a cognitive task. Notably, altered brain connectivity during cognitive challenges was often found to be associated with psychopathological measures, suggesting a mechanistic relation between functional network integrity and the clinical expression of psychosis. Several works proposed that disordered brain connectivity in psychosis results from abnormal N-methyl- D -aspartate receptor (NMDAR)-dependent synaptic plasticity, which can be mediated by other neurotransmitter systems such as dopamine or serotonin. Specific chemically mediated changes in synaptic plasticity may contribute to abnormal functional integration among brain regions and in consequence to impaired learning performances and inferences. Model-based connectivity investigations on synaptic signalling demonstrated for example that manipulation of the NMDA or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor system altered synaptic plasticity in healthy volunteers, which was predictive for subjects' cognitive performance and psychopathology. In patients with psychosis, the activity in the prefrontal cortex during the processing of prediction errors, a specific form of learning, which is conveyed via synaptic connections, was linked with individuals' formation of delusions. These results fit well with many works suggesting that psychotic symptoms or also drug-induced psychosis-like experiences can be explained by disturbances within a hierarchically organized neuronal network, leading to maladaptive integrations of new incoming evidence and thereby to false formations of prediction errors and false beliefs. In this research topic, we like to cover the most recent neurobiological correlates for early stage psychosis and in particular for the prediction of psychosis by using different neurophysiological measures (e.g. structural and functional MRI, EEG, DTI or PET). Studies exploring effective connectivity or complex brain networks such as small-world properties with techniques like dynamic causal modelling, structural equation modelling, or graph theory analysis are highly appreciated. Very welcome are studies proving a link between clinical features such as psychopathology and cognition, brain signals, and chemistry (also in regard of antipsychotic treatments or substance-induced psychotic states). Moreover, environmental factors that may influence psychosis onset or its' developmental processes will be brought together with a diversity of different research modalities. We also collect critical reviews, mini-reviews or theoretical reflections from leading international researcher and clinicians in this field. The purpose of our research topic is intended to provide a state-of-the-art cognitive perspective to consider developing psychosis, which might shed more lights into the pathophysiological and neurobiological mechanisms of psychosis. |
| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
| Terms governing use and reproduction | Creative Commons |
| Use and reproduction rights | https://creativecommons.org/licenses/by/4.0/ |
| Source of term | cc |
| Uniform Resource Identifier | <a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a> |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medicine and Nursing |
| Source of heading or term | bicssc |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cognition |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Computational Psychiatry |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | dysfunctional brain connectivity |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | early detection and intervention |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neuroimaging |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pharmacology |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | prevention |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | psychopathophysiology |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | psychosis |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | psychosis high-risk state |
| 720 1# - ADDED ENTRY--UNCONTROLLED NAME | |
| Name | Andre Schmidt |
| Relationship | aut |
| 720 1# - ADDED ENTRY--UNCONTROLLED NAME | |
| Name | Stefan Borgwardt |
| Relationship | aut |
| 793 0# - | |
| -- | DOAB Library. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://journal.frontiersin.org/researchtopic/1206/neuropsychopharmacology-of-psychosis-relation-of-brain-signals-cognition-and-chemistry">http://journal.frontiersin.org/researchtopic/1206/neuropsychopharmacology-of-psychosis-relation-of-brain-signals-cognition-and-chemistry</a> |
| Access status | 0 |
| Public note | Open Access: DOAB, download the publication |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://directory.doabooks.org/handle/20.500.12854/54531">https://directory.doabooks.org/handle/20.500.12854/54531</a> |
| Access status | 0 |
| Public note | Open Access: DOAB: description of the publication |
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